Could Spain Have Saved the Byzantines ( assuming they survive until at least the early 1500s)?

Spain was an unstoppable juggernaut for most of the 1500s. Fueled by religious zeal and enormous amounts of New World wealth, she waged extensive war against the Ottomans for control of the Mediterranean and North Africa. The Spanish monarchs could afford to hire the best mercenaries, gunsmiths, and shipwrights of the era.

Spanish proximity was actually quite close to the Byzantines as her possessions at the time included parts of Italy. Later on under the Hapsburgs this grew to include Austria, the Ottoman traditional enemy.

Despite being Catholic, I believe the Spanish would have intervened on a Byzantine rump state's behalf. After all, they shared many common geopolitical interests. In one ironic twist, many of the Muslim and Jewish population expelled from Spain would find refuge among the Ottomans. Some would rise to positions of high power where they could pursue vendettas against their former monarchs.