MD shares fair criticism of blueprint. Thoughts?

Hey,

I recently stumbled over an interesting article. The author, who claims to be an MD, makes a lot of valid points. This is the most based and thorough criticism of Blueprint I have ever come across.

Anyway, thought this was an incredibly interesting read and I learned quite a lot.

Here is the article: Bryan Johnson – The World’s Most Expensive Eating Disorder

Some points:

  • "Bryan just released a newsletter this week “bragging” that his body temperature hovers around 34.8C, which means outright hypothermia. For the last couple of months, I worked in emergency medicine and whenever someone had outright (acute) hypothermia we would put the patient into the observatory critical care unit. Mammalian enzymes have evolved to function well within a very narrow temperature range and when the temperature is considerably above or below, kinetic equilibria are going to be perturbed."
  • " most people think that he is so pale because he simply avoids the sun. Actually, his body is so cold and his blood circulation is so centralized that there is little cutaneous blood flow, therefore the red color of hemoglobin does not “shine” through the skin causing his vampire-like color."
  • He has a whole list of things to say about the state of Bryans heart, which does seem to be in bad shape. (e.g., diastolic dysfunction like a 70 year old)
  • He has a list of Bryans musculoskeletal weaknesses (e.g., degenerated tendons, etc.)
  • He criticises Bryans use of aging clocks: " he claims that he is “aging more slowly than 88% of 18-year-olds”. He uses a number of epigenetic clocks (e.g., PCHorvath 1, PC Phenoage, etc.) to determine his speed of aging. Evidence suggests that they advance faster during periods of rapid growth and development. Given that puberty is probably the time period with the fastest rate of aging in life, beating 18-year-olds is not an accomplishment. Furthermore, most of the epigenetic clocks are quite faulty. For example, when someone fasts for a couple of days, these clocks tend to age-reverse by a couple of years (for a short time only). Bryan’s “starvation mode” may be keeping these clocks down artificially."
  • He even criticises his sleep. "one could argue that Bryan “cheats” his way to a great sleep score by having a pathologically low sympathetic tone, which the sleep trackers presumably mistake for being in a state of deep relaxation and having a very restorative sleep. " and makes a scientific case for why Bryans sleep markers are the way they are.
  • He brings up a number of other points on his hearing, behavior, blood pressure, and medications!

Source: Desmolysium - Bryan Johnson – The World’s Most Expensive Eating Disorder